Welcome to the Department of Public Health, Graduate School of Public Health, Kumamoto University!

Human health & disease condition is determined by the complex interplay between genetic susceptibility and environmental exposure including life style. We are interested in the study of discovering the genetic and environmental causes of the diseases. Understanding genetic susceptibility to environmental agents will allow more precise identification of the environmental agents that cause disease and the true risks of exposures. We are currently engaging in the research projects as follows: 1) identification of functionally important genetic markers of carcinogen susceptibility; and 2) molecular epidemiological studies of gene-environmental interactions in cancer etiology. This can lead to more effective disease prevention and the improvement of public health. Furthermore, we conduct preventive approach on the bone mineral density in the focus on life style and body composition in young females.

Takahiko Katoh, Professor

2008

1. Omori H., Fujimoto K., Katoh T.
   Computed tomography findings of emphysema: correlation with spirometric values.
   Current Opinion in Pulmonary Medicine, in press (March 2008)
2. Katoh T., Yamano Y., Tsuji M., Watanabe M.                                               
   Genetic polymorphisms of human cytosol glutathione S-transferases and prostate cancer.                                                                       
   Pharamacogenomics 9(1), 93-104 (2008)   
3. Sasaki T., Matsumoto N., Nakao H., Katoh T., Fukuda Y., Nakazato M., Okayama A.                                                                                                                       
   An outbreak of legionnaires' desease associated with a circulating bath water at a public bathhouse: A clinical analysis.                                                            
   Infect Chemother (in press)     
4. Matsumoto N., Sasaki T., Nakao H., Katoh T., Fukuda Y., Nakazato M., Okayama A.                                                                                                                      
   An outbreak of legionnaires' disease associated with a circulating bath water system at a public bathhouse: Radiological findings of pneumonia.                   
   J Infet Chemother (in press)

2007

1. Kohshi K., Yamamoto H., Nakahara A., Katoh T., Takagi M.
   Fractionated stereotactic radiotherapy using gamma unit after hyperbaric oxygenation on recurrent high-grade gliomas.
   J Nuerooncol 82, 297-303 (2007)
2. Matsunaga T., Maruyama K., Takeyama H., Katoh T.
   High-through SNP detection using nano-scale engineered biomagnetite.
   Biosens Bioelectron 22, 2315-2321 (2007)
3. Kuroda Y., Nakao H., Ikemura K., Katoh T.
   Association between the TP53 codon72 polymorphism and oral cancer and prognosis.
   Oral Oncol (2007) [Epub ahead of print]
4. Tsuchiya M., Tsukino H., Iwasaki M., Sasaki H., Tanaka T., Katoh T., Patterson Jr DG., Turner W., Needham L., Tsugane S.
   Interaction between cutochrome P450 gene poloymorphisms and serum organochlorine TEQ levels in the risk of endometriosis.
   Mol Hum Reprod 13, 399-405 (2007)
5. Tsuchiya M., Miura T., Hanaoka T., Iwasaki M., Sasaki H., Tanaka T., Nakao H., Katoh T., Ikenoue T., Kubota M., Tsugane S.
   Effect of soy isoflavones on endometriosis, interaction with estrogen receptor 2 gene polymorphism.
   Epidemiology 18, 402-408 (2007)
6. Kawamoto T., Yang M., Kim YD., Kim H., Oyama T., Isse T., Matsuno K., Katoh T., Uchiyama I.
   Effects of Lifestyle on Urinary 1-hydroxypyrene Concentration.
   J Occup Health 49, 183-189 (2007)
7. Katoh T., Kuroda Y., Komiya Y.
   Questionnare survey of factory workers regarding chemical sensitivity.
   J Occup Health 49, 98-99 (2007)
8. Omori H., Nonami Y., Mihara S., Marubayashi T., Morimoto Y., Aizawa H.
   Prevalence of airflow limitation on medical check-up in Japanese subjects.
   J UOEH 29(3), 209-219 (2007)
9. Takeda O., Takeuchi S., Ito S., Omori H., Katoh T., Yamaguchi T.
   Effects of phenyl derivatives of dihydropyrazines with ability to generate radical species onEscherichia coli.
   Biol. Pharam. Bull. 30(9), 1663-1667 (2007)
10. Tsukino H., Omori H., Koshi K., Yamamo Y., Katoh T.
    Molecular epidemiology and urothelial cancer.
    J UOEH 29, 265-289 (2007)
11. Naito H., Kamijima M., Yamanoshita O., Nakahara A., Katoh T., Tanaka N., Aoyama T., Gonzales FJ., Nakajima T.
    Differential effects of aging drinking and exercise on serum cholesterol levels depending on PPARα V227A polymorphism.
    J Occup Health (in press)
12. Omori H., Sata K., Saitoh R., Mihara S., Marubayashi T., Narimatsu A., Kawanaka K., Tomiguchi S.
    A case of report of intralobar pulmonary sequestration detected by lung cancer screening with low-dose spiral CT.
    J UOEH 29(3), 259-263 (2007)
13. Omori H., Koga T., Tsuda T., Arizawa H. and Fukuoka COPD Research Group
    Epidemiological survey of unidentified chronic obstructive pulmonary disease (COPD).
    Pharma Medica 25(7), 151-156 (2007) in Japanese
14. Muhammad A., Ando T., Maaz A., Ghani S., Munir M., Qureshi IV., Naeems S., Tsuji M., et al.
    Scalp hair mercury levels in Pakistan.
    Environ. Sci. 24, 167-175 (2007)
15. Tsuji M., Koriyama C., Inaba Y., Akiba S
    Concordance of CAP-RAST responses for food and indoor allergens between sibling pairs with atopic dermatitis.
    Med. J. Kagoshima (in press)
    

2006

1. Komiya Y., Nakao H., Kuroda Y., Arizono K., Nakahara A., Miyauchi M., Katoh T.
   Relationships of Change in radius bone mineral density for seven years of working women around thirty years old with lifestyle, body measurement data and laboratory data.
   Jpn J Hyg 61, 327-331 (2006)
2. Komiya Y., Nakao H., Kuroda Y., Arizono K., Nakahara A., Katoh T.
   Application of aldehyde dehydrogenase 2 (ALDH2) genetic diagnoses on support of decreasing alcohol intake.
   J Occup Health 48, 161-165 (2006)
3. Naito H., Yamanoshita O., Kamijima M., Katoh T., Matsunaga T., Lee C.H., Kim H., Aoyama T., Gonzales FJ., Nakajima T.
   Association of V227A PPARαpolymorphism with altered serum biochemistry and alcohol drinking in Japanese men.
   Pharamacogenet Genomics 16, 569-577 (2006)
4. Kosaka T., Yoshino J., Inui K., Wakabayashi T., Okushima K., Kobayashi T., Miyoshi H., Nakamura Y., Hayashi S., Shiraishi T., Watanabe M., Yamamoto T., Nakahara A., Katoh T.
   Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis.
   World J Gastroenterol 12, 6325-6330 (2006)
5. Ohtsuka S., Kitano T., Maeda Y., Azami S.
   Effect of the protein and oil contents on calcium utilization in the diets of female fischer rats that were fed by three different feeding methods.
   J Nutr Sci Vitaminol 52, 316-326 (2006)
6. Omori H., Nakashima R., Otsuka N., Mishima Y., Tomiguchi S., Narimatsu A., Nonami Y., Mihara S., Koyama W., Marubayashi T., Morimoto Y.
   Emphysema detected by lung cancer screening with low-dose spiral CT: Prevalence, and correlation with smoking habits and pulmonary function in Japanese male subjects.
   Respirology 11, 205-210 (2006)
7. Koga T., Tsuda T., Omori H., Yano H., Watanabe K., Arizawa H. and Fukuoka COPD Research Group
   Epidemiological survey of unidentified COPD in medical check-up participants, primary care visitors and preoperative patients in the Kyushu area of Japan.
   Respiration Research 25(8), 801-806 (2006)

2005

1. Qiu D., Chu CP., Tsukino H., Shirasaka T., Nakao H., Kato K., Kunitake T,. Katoh T., Kannan H.
   Neuromedin U receptor-2-mRNA and HCN channels mRNA expression NMU-sensitive neurons in rat hypothalamic paraventricular nucleus.
   Neurosci Lett 374, 69-72 (2005)
2. Tatemichi M., Sawa T., Gilibert I., Tazawa H., Katoh T., Ohshima H.
   Increased risk of intestinal type of gastric adenocarcinoma in Japanese women associated with long forms of CCTTT pentanucleotide repeat in the inducible nitric oxide synthase promoter.
   Cancer Lett 217, 197-202 (2005)
3. Komiya Y., Tsukino H., Nakao H., Kuroda Y., Imai H., Katoh T.
   Human glutathione S-transferase A1 polymorphism and susceptibility to urothelial cancer in the Japanese population.
   Cancer Lett 221, 55-59 (2005)
4. Kohshi K., Wong R., Abe H., Katoh T., Okudera T., Mano Y.
   Neurological manifestations in Japanese Ama divers.
   Undersea Hyperb Med 32, 11-20 (2005)
5. Komiya Y., Tsukino H., Nakao H., Kuroda Y., Imai H., Katoh T.
   Human glutathione S-transferase A1, T1, M1, and P1 polymorphisms and susceptibility to prostate cancer in the Japanese population.
   J Cancer Res Clin Oncol 131, 238-242 (2005)
6. Tsuchiya M., Nakao H., Katoh T., Sasaki H., Hiroshima M., Tanaka T., Matsunaga T., Hanaoka T., Tsugane S., Ikenoue T.
   Association between endometriosis and genetic polymorphisms of the estradiol-synthesizing enzyme genes HSD17B1 and CYP19.
   Human Reprod 20, 974-978(2005)
7. Tsuruta K., Fujii Y., Maeda H., Murakata T., Katoh T.
   Mental health status and effects on daily life style of patients of a large outbreak of Legionnaires disease.
   Jap J Public Health 52, 308-318 (2005)
8. Komiya Y., Nakao H., Kuroda Y., Arizono K., Nakahara A., Katoh T.
   Consciousness survey regarding genetic diagnosis of glutathione S-transferase M1 (GSTM1) and aldehyde dehydrogenase 2 (ALDH2) polymorphism.
   J Occup Health 47, 204-209 (2005)
9. Qiu D., Chu CP., Shirasaka T., Tsukino H., Nakao H., Kato K., Kunitake T., Katoh T., Kannan H.
   Corticotropin-releasing factor augments the IH in rat hypothalamic paraventricular nucleus parvocellular neurons in vitro.
   J Neurophysiol 94, 226-234 (2005)
10. Takeda O., Takechi S., Katoh T., Yamaguchi T.
    The role of Dihydropyrazines in accelerated death of Eschetichia coli on addition of Copper (ll).
    Biol Pharam Bull 28, 1161-1164 (2005)
11. Tsuchiya M., Katoh T., Motoyama H., Sasaki H., Tsugane S., Ikenoue T.
    Analysis of the AhR, ARNT, and AhRR gene polymorphisms, genetic contribution to endometriosis susceptibility and severity.
    Fertil Steril 84, 454-458 (2005)
12. Komiya Y., Kuroda Y., Nakao H., Arizono K., Nakahara A., Katoh T.
    Human glutathione S-transferase A1 polymorphisms and susceptibility to oral squamous cell carcinoma in Japanese.
    Environ Health Prev Med 10, 331-334 (2005)
13. Imai H., Hosomi J., Nakao H., Tsukino H., Katoh T., Itoh T., Yoshida T.
    Characteristics of psychiatric hospitals associated with length of stay in Japan.
    Health Policy 74, 115-121 (2005)
14. Futatsuka M., Kitano T., Shono M., Nagano M., Wakamiya J., Miyamoto K., Ushijima K., Inaoka T., Fukuda Y., Nakagawa M., Arimura K., Osame M.
    Long-term follow-up study of health status in population living in methylmercury-polluted area.
    Environ Sci 12, 239-282 (2005)
15. Kitano T.
    Bacic and epidemiological studies on calcium nutrition for Japanese people.
    Jpn J Nutr Diet 63, 253-259 (2005)
16. Ushijima K., Shono M., Kitano T., Futatsuka M.
    Factors relating to the conditions and characteristics of mental health among the inhabitants in a methylmercury polluted area.
    Jpn J Hyg 60, 345-354 (2005)
17. Omori H., Nonami Y., Morimoto Y.
    Effect of smoking on FEV1 decline in a cross-sectional and longitudinal study of a large cohort of Japanese males.
    Respirology 10, 464-469 (2005)