熊本大学大学院 生命科学研究部 環境生命科学講座 公衆衛生学分野では、疫学に分子生物学の視点・技術をとりいれた分子疫学を基盤に予防医学と環境医学研究を行っています。

助教 宮崎 航 (Wataru Miyazaki)

Home > 教室紹介 > 助教 宮崎 航 (Wataru Miyazaki)

助教 宮崎 航 (Wataru Miyazaki)

1.経歴

2002.3      鳥取大学 医学部 生命科学科 卒業
2004.3      鳥取大学大学院医学系研究科 博士前期課程 修了
               (群馬大学特別研究生)
2008.3      群馬大学大学院医学系研究科 博士課程修了 医学博士(PhD)
2011.3      東京大学大学院医学系研究科 疾患生命工学センター 健康環境医工学
              特任研究員
2011.4~     熊本大学大学院 医学薬学研究部 公衆衛生・医療科学分野 助教
 



 

2.研究内容
  • 神経毒性学
  • 環境生理学
【具体的な研究テーマ】
脳発達における環境化学物質の影響に関する研究
1.    環境化学物質の作用機構の解明
        1) 神経系細胞を用いた曝露により変動する分子の同定
        2) 化学物質の作用部位・分子の同定
2.     個体の表現型を反映するin vitro代替実験法の確立
        1) 曝露により変動する分子マーカーの探索
        2)ヒトのリスク評価に有用な毒性スクリーニング法の開発
 



 

3.学会活動
  • 日本衛生学会
  • 日本環境ホルモン学会
 
4.社会活動・その他
  •  
  •  
 
5.研究業績
 
【論文・著書・総説】
 
2013年
1.    Cui X, Lu X, Hiura M, Omori H, Miyazaki W, Katoh T. Association of genotypes
      of carcinogen-metabolizing enzymes and smoking status with bladder cancer
      in a Japanese population. Environ Health Prev Med. 18:136-42, 2013.
2.     Cui X, Lu X, Hiura M, Miyazaki W, Oda M, Katoh T. Evaluation of Genetic Polymorphisms in
      Patients with Multiple Chemical Sensitivity. Plos One. 8, 2013.

 

2012年

1.    Lu X, Chen Z, Cui X, Uji M, Miyazaki W, Oda M, Nagata T, Kitamura T, Katoh T.
      Effects of temperament and charater profiles on state and trait depression and
      anxiety: a prospective study of a Japanese youth population.
      Depress Res Treat. 2012:604684, 2012.



2011年

1.     Endo T, Maekawa F, Võikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M. Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage. Behavioral Brain Research. 221(1):172-181. 2011.
2.      Ibhazehiebo K, Iwasaki T, Kimura-Kuroda J, Miyazaki W, Shimokawa N, Koibuchi N. Disruption of Thyroid Hormone Receptor-Mediated Transcription and Thyroid Hormone-Induced Purkinje Cell Dendrite Arborization by Polybrominated Diphenylethers. Environmental Health and Perspectives 119(2):168-75. 2011.
 
2010
1.      Haijima A, Endo T, Zhang Y, Miyazaki W, Kakeyama M, Tohyama C. In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice. Neurotoxicology 31(4):385-390, 2010.
2.      Amano I*, Miyazaki W*, Iwasaki T, Shimokawa N, Koibuchi N. (*contributed equally) The effect of hydroxylated polychlorinated biphenyl (OH-PCB) on thyroid hormone receptor (TR)-mediated transcription through native-thyroid hormone response element (TRE). Industrial Health. 48(1):115-118, 2010.
3.      Londoño M, Shimokawa N, Miyazaki W, Iwasaki T, Koibuchi N. Hydroxylated PCB induces Ca2+ oscillations and alterations of membrane potential in cultured cortical cells. Journal of Applied Toxicology 30(4):334-42, 2010.
 
2009
1.      Qiu CH*, Miyazaki W*, Iwasaki T, Londoño M, Ibhazehiebo K, Shimokawa N, Koibuchi N. (*contributed equally) Retinoic Acid receptor-related orphan receptor alpha-enhanced thyroid hormone receptor-mediated transcription requires its ligand binding domain which is not, by itself, sufficient: possible direct interaction of two receptors. Thyroid. 19(8):893-898, 2009.
2.      Odawara H, Iwasaki T, Horiguchi J, Rokutanda N, Hirooka K, Miyazaki W, Koibuchi Y, Shimokawa N, Iino Y, Takeyoshi I, Koibuchi N. Activation of aromatase expression by retinoic acid receptor-related orphan receptor (ROR)beta in breast cancer cells: Identification of a novel ROR response element Journal of Biological Chemistry 284(26):17711-17719, 2009.
 
2008
1.      Koibuchi N, Qiu CH, Miyazaki W, Iwasaki T, Shimokawa N. The role of thyroid hormone in developing cerebellum. Cerebellum 7(3):499-500, 2008.
2.      Rokutanda N, Iwasaki T, Odawara H, Nagaoka R, Miyazaki W, Takeshita A, Koibuchi Y, Horiguchi J, Shimokawa N, Iino Y, Morishita Y, Koibuchi N. Augmentation of estrogen receptor-mediated transcription by steroid and xenobiotic receptor. Endocrine 33: 305-316, 2008.
3.      Iwasaki T, Miyazaki W, Rokutanda N, Koibuchi N.  Liquid chemiluminescent DNA pull-down assay to measure nuclear receptor-DNA binding in solution. Biotechniques 45(4):445-448, 2008.
4.      Miyazaki W, Iwasaki T, Takeshita A, Tohyama C, Koibuchi N.  Identification of Functional Domain of Thyroid Hormone Receptor Responsible for Polychlorinated Biphenyl-mediated Suppression of Its Action in vitro. Environmental Health and Perspectives 116(9):1231-1236, 2008.
 
2007年以前
1.      Miyazaki W, Londono MB, Iwasaki T, Shimokawa N and Koibuchi N. Possible mechanism of PCB actions, which are not Mediated by AhR Persistent Organic Pollutants(POPs) Research in Asia 289-291, 2007.
2. Iwasaki T, Takeshita A, Miyazaki W, Chin WW, Koibuchi N. The interaction of TRbeta1-N terminus with steroid receptor coactivator-1 (SRC-1) serves a full transcriptional activation function of SRC-1. Endocrinology 147(3):1452-1457, 2006.
3.      Shimokawa N, Miyazaki W, Iwasaki T, Koibuchi N.Low dose hydroxylated PCB induces c-Jun expression in PC12 cells. Neurotoxicology 27(2):176-183, 2006.
4.      鯉淵典之、岩崎俊晴、宮崎航、岡田淳一、下川哲昭、竹下彰、黒田洋一郎 甲状腺ホルモンの中枢作用に及ぼす内分泌かく乱物質の影響   ホルモンと臨床53(1) 75-80, 2005.
5.   鯉淵典之、岩崎俊晴、宮崎航、Yousefi Behnaz、梅津元昭、黒田洋一郎 甲状腺ホルモンによる遺伝子発現とPCB類によるかく乱   Brain Medical 16(4) 345-350, 2004.
6.      Miyazaki W, Iwasaki T, Takeshita A, Kuroda Y, Koibuchi N. Polychlorinated Biphenyls (PCBs) Suppress Thyroid Hormone (TH) Receptor (TR)-mediated Transcription Through a Novel Mechanism. Journal of Biological Chemistry 279(18):18195-18202, 2004.
7.      Koibuchi N, Ohta M, Miyazaki W, Jingu H, Yousefi Behnaz, Shimokawa N, Iwasaki T, Okada J. Effects of Thyroid Hormone and Endocrine Disrupters on Gene Expression in the Developing Central Nervous System    Environmental Sciences 10035-10042, 2003.
8.      Iwasaki T, Miyazaki W, Takeshita A, Kuroda Y, Koibuchi N. Polychlorinated biphenyls (PCBs) suppress thyroid hormone-induced transactivation Biochemical and Biophysical Research Communications 299:384-388, 2002. 

 

 

▲このページのTOPに戻る